Inflammatory cytokines may mediate cognitive dysfunction and sickness behavior during acute illness
نویسندگان
چکیده
منابع مشابه
Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration
Inflammation influences chronic neurodegeneration but its precise roles are not yet clear. Systemic inflammation caused by infection, trauma or co-morbidity can alter the brain's inflammatory status, produce acute cognitive impairments, such as delirium, and drive new pathology and accelerated decline. Consistent with this, elevated systemic TNF-α is associated with more rapid cognitive decline...
متن کاملProinflammatory cytokines, sickness behavior, and Alzheimer disease.
BACKGROUND In Alzheimer disease (AD), systemic inflammation is known to give rise to a delirium. However, systemic inflammation also gives rise to other centrally mediated symptoms in the absence of a delirium, a concept known as sickness behavior. Systemic inflammation is characterized by the systemic production of the proinflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-6 ...
متن کاملAssociation between endothelial dysfunction and acute brain dysfunction during critical illness.
BACKGROUND Acute brain dysfunction (delirium and coma) during critical illness is prevalent and costly, but the pathophysiology remains unclear. The relationship of acute brain dysfunction with endothelial function, which is impaired in critical illness and may contribute to alterations in cerebral blood flow and blood-brain barrier permeability, has not been studied. This study sought to deter...
متن کاملSickness-induced Cognitive Dysfunction: Molecular, Physiological, and Behavioural Correlates
Activated immune cells secrete proinflammatory cytokines that induce a generalized sickness response. The following experiments were designed to determine whether the proinflammatory cytokine IL-1β is the peripheral mediator of sickness-induced cognitive dysfunction, as well as to characterize the cognitive processes that are disrupted during illness. The effects of peripherally-administered IL...
متن کاملNeutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.
High concentrations of neutrophil defensins from airway and blood have been reported in patients with inflammatory lung diseases, but their exact role is unclear. We investigated the direct effect of defensins on the lungs of mice. Intratracheal instillation of purified defensins (5-30 mg/kg) induced a progressive reduction in peripheral arterial O(2) saturation, increased lung permeability, an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2017
ISSN: 0022-510X
DOI: 10.1016/j.jns.2017.08.284